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Nuclear imaging has the benefits of high intrinsic sensitivity, recognising targets present in a very low concentration, exceptional penetration of tissues, whole-body visualisation, and a large range of available, clinically tested tracers and consequently a high specificity [ 1, 2].
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Radar micro-Doppler signatures are generally both target and action specific and hence can be used to classify and recognise targets as well as to identify possible threats.
Both antibodies recognise targets that are overexpressed on tumour cells relative to normal tissue, and overexpression of both targets was found to correlate negatively with overall patient survival.
For instance, tumour infiltrating lymphocytes capable of killing autologous bladder tumour cells in 2D, failed to recognise targets when cultured in 3D (Dangles et al, 2002).
Serotype specific clones showed intermediate (D9, 10A4 and 3H9) activity against their cognate peptides (pD3/4, pD2, pD2 respectively) but failed to recognise target cells pulsed with the peptide variants (Fig 3c).
The complexity of the NK cell compartment is attributable to the vast network of receptors that are expressed on NK cell surfaces, which allow them to recognise target cells.
It is widely assumed that CHD is caused by haploinsufficiency and an inability of mutant proteins to recognise target genes.
When CTLs or NK cells recognise target cells, they become activated and express FasL, which binds to Fas receptors on the surface of the target cells and induce target cell apoptosis (Leithauser et al, 1993; Suda et al, 1993; Suda and Nagata, 1994; Nagata, 1997).
Furthermore, a mismatch at target site 4 occurs within the miRNA seed sequence important for recognising the target sequence, presumably making it difficult for this target site to be cleaved by miR399.
First, the theory adopt a mechanistic approach (e.g., Bechtel 2008; Craver 2007) suggesting a way to decompose a tracker's agent-identification behaviour into specific tracking mechanisms and processes, such as those involved in recognising a target agent and reasoning about that target's causal history.
Despite the limited size of the pairing region, the sRNAs recognise targets with selectivity and affect rapid responses, which is most often by repressing translation and triggering degradation of the targeted mRNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com