Intelligence is a word he uses often, recognising Test rugby is no longer just about power, although it remains an essential quality, but pace, athleticism and understanding.
Now that I had an antiserum that recognised mouse T cells, I wanted to visualise directly the antibodies binding to the T cell surface.
Although the breakpoint region of the characteristic EWS-FLI1 fusion protein contains unique peptide sequences specifically recognised by T cells (Meyer-Wentrup et al, 2005), clinically tested fusion peptides failed to induce high-avidity T-cell responses (Mackall et al, 2008).
Thus, cattle and humans appear to recognise similar T cell epitopes on the F protein.
Recently, recombinant Ag85B was combined with a second Mtb-specific antigen TB10.4 [10] [10] that is strongly recognised by T cells from both BCG-vaccinated and TB patients [9].
First, there is a strong rationale for identifying HIV-1 peptides presented by distinct MHC class I molecules that may be recognised by T cells and/or NK cells in vivo.
Identification of the ligands recognised by T cells and NK cells facilitates analysis and manipulation of lymphocyte subsets participating in host defence and in disease processes, and can help mediate the development of immune-based prophylactic and therapeutic strategies including vaccines.
Today, more than 50 melanoma-associated epitopes are known, which can be recognised by T cells.
Tumour-associated antigens recognised by T cells have been reported, and therapeutic trials utilizing tumour vaccines are now ongoing (Henderson and Finn, 1996; Melief et al, 2000; Rosenberg 2001).
Cancer cells also produce mutated epitopes and these can be recognised by T cells (Lu et al., 2013; Robbins et al., 2013; Lu et al., 2014), and CAR T-cell therapies targeting mutated targets are in clinical trials.
