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It is generally recognised that the study of intraplate earthquakes is a difficult task because their seismogenic faults may have minor features, strain rates are low, and large size earthquakes are infrequent (Dunn and Chapman, 2006).
It is, however, recognised that the study has a number of limitations.
It is recognised that the study has low power to detect interactions, therefore, an interaction test which is not statistically significant does not mean that there really is no interaction.
Researching potentially sensitive and emotive topics : It must be recognised that the study participants may already have psychological sequalae (eg, post-traumatic stress symptoms) as a result of the critical illness experience.
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It was recognised that the studies would be heterogeneous both in terms of the cohorts and the criteria used to define anaemia, so that any planned analysis should be simple and in large part qualitative.
Also we have to recognise that the study was underpowered at outset for these secondary outcome measures, added to which the proportions responding to the patient-directed enquiries were about 30%%.
We recognise that the study also has some limitations.
Thus, the findings should be taken with caution, recognising that the study took place with a specific population, and is time and context specific.
The present post hoc exploratory analysis was performed to assess the outcomes of patients treated in the phase III registration trial of enzalutamide vs placebo (AFFIRM) in EU and NA, recognising that the study was not powered or designed to assess (or account for) regional differences at baseline.
We recognise that the studies are heterogeneous because of differences in follow-up time, patient population, surgical technique and threshold for defining local treatment failure or local recurrence.
23 It was recognised that the SUGAR study and the imaging review may have some limitations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com