It is consistent with the long recognised differences in pathogenicity and efficacy of anti-microbial drug treatments between MAP and M. tuberculosis infections in humans [63] the genetic basis for which is beginning to emerge [64].
Cell death manipulation is a recognised strategy for augmenting the efficacy of whole-cell cancer vaccines (Copier and Dalgleish, 2006).
Both cisplatin plus 5-fluorouracil (CF) (Kim et al, 1993; Vanhoefer et al, 2000; Ohtsu et al, 2003; van Cutsem et al, 2006) and epirubicin plus CF (ECF) (Webb et al, 1997; Ross et al, 2002) have established efficacy and are recognised reference regimens for comparative trials.
Randomised, controlled trials of good quality are a recognised means to robustly assess the efficacy of interventions in clinical practice.
Moreover, as it is now well-recognised that ignoring patients' or partners' baseline distress can undermine the efficacy of an intervention (given the potential for floor effect) [ 63], distressed patients or partners are included in this study.
26 A pragmatic design is a recognised methodology for tackling questions on effectiveness in daily practice as opposed to efficacy in a "controlled" setting.
The purpose of this investigation was to determine if low self-efficacy was associated with poor self-rated oral health, a recognised proxy marker of both clinical oral health status [ 13] and oral health-related quality of life [ 14], among a convenience sample of Australian women pregnant with an Aboriginal child.
The efficacy of oral vitamin K is less certain as there is a recognised problem of absorption in some babies, and additional difficulties in compliance with multiple-dose oral regimens (Zipursky, 1999; Wariyar et al, 2000; von Kries et al, 2003).
In light of this, patient derived tumour tissue xenograft models are increasingly recognised as offering the most robust approach for testing tumour responses to various chemotherapeutic regimens, evaluating the efficacy of novel therapeutic agents, analysing the process of tumour progression at the cellular and molecular level and the identification of new therapeutic targets [ 2].
It's a recognised problem.
