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Also we have to recognise that the study was underpowered at outset for these secondary outcome measures, added to which the proportions responding to the patient-directed enquiries were about 30%%.
We recognise that the study also has some limitations.
We were unable to recruit the desired number of infants and recognise that the study may be underpowered.
Therefore, we did not undertake sample size calculations and recognise that the study is underpowered to draw conclusions about homebirth and rare perinatal outcomes.
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We recognise that the studies are heterogeneous because of differences in follow-up time, patient population, surgical technique and threshold for defining local treatment failure or local recurrence.
Dr Doug Brown, director of research and development at the Alzheimer's Society, also recognised that the study "adds evidence to the idea that gum disease could potentially be a contributing factor to Alzheimer's".
It is generally recognised that the study of intraplate earthquakes is a difficult task because their seismogenic faults may have minor features, strain rates are low, and large size earthquakes are infrequent (Dunn and Chapman, 2006).
It is, however, recognised that the study has a number of limitations.
Thus, the findings should be taken with caution, recognising that the study took place with a specific population, and is time and context specific.
It is recognised that the study has low power to detect interactions, therefore, an interaction test which is not statistically significant does not mean that there really is no interaction.
Researching potentially sensitive and emotive topics : It must be recognised that the study participants may already have psychological sequalae (eg, post-traumatic stress symptoms) as a result of the critical illness experience.
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