The net reclassification index was significantly improved by the addition of H-FABP as well as the addition of hsTnT to traditional risk factors.
The classification systems differ significantly and reclassification is problematic.
We also assessed the predictive value of the reclassification for variables that significantly differed between the groups.
Adding OPG tertile 3 versus tertiles 1 and 2 to a risk marker model that included BNP and hs-CRP resulted in significantly improved reclassification of patients (p<0.0001).
Adding the sum of PCBs to the risk factors described above resulted in significantly improved reclassification with both methods (estimate 0.013, SE 0.0065, and P = 0.034 for IDI and estimate 0.22, SE 0.11, and P = 0.045 for NRI).
While the results on discrimination indicated that model B was better than model A at distinguishing between individuals with and without the disease, results from the NRI statistic suggested that this difference did not significantly improve reclassification.
50 In contrast, and similar to the findings for all cause dementia, addition of all three magnetic imaging variables or hippocampal volume to the conventional risk model significantly improved reclassification, measured with the integrated discrimination index, and the decision curve analysis resulted in higher net benefit, however, as explained above, caution is required in the interpretation.
49 Although this genotype added minimally to the ability of the Framingham risk score to discriminate future events, improving the area under the receiver operating characteristics curve by only 3%, it did significantly improve reclassification of risk of coronary heart disease, albeit modestly.
In a net reclassification improvement model, slope 5 significantly improved the predictive power of LODS; Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in MODS.
No less than the NIH director then, James Wyngaarden, wrote to the agency to protest the reclassification, arguing that it could "significantly compromise our current ability to make selective use of chimpanzees in research to fight human disease".
