In order to assess whether MFH reclassification using our 170-gene predictor is tracking specific oncogenic pathway activation patterns, we evaluated the activation status of Src, Ras and PI3K pathways in the 30 MFH samples of the U133 datasets using the aforementioned gene expression "readouts".
We therefore conducted sensitivity subanalysis to differentiate between smokers who quit for less than 1 day and those who quit for 1 179 days in order to provide a stricter reclassification of the smoking group.
Pepe et al. [ 33] recently suggested calculating the NRI and IDI measures when comparing two scores, in order to assess whether any reclassification was in the right or wrong direction.An example from our previous research illustrates some of these analytical approaches [ 34].
In order to assess whether our MFH reclassification reflected true molecular similarity of the reclassified MFH samples with their corresponding STS subtypes, we performed unsupervised hierarchical clustering of all tumors (including MFH samples) within each dataset using the complete linkage method and the one minus centered correlation as a distance metric [37].
binding site residues are shown by default in white and with a wireframe style in order to show the context where the possible reclassification is evaluated.
In order to minimize possible reporting biases, such as underreporting or reclassification to a lower level of severity, injury statistics are elaborated starting from data collected directly on-site, from internal accident or medical-aid reports.
Once established, modifications to the four letter abbreviations are strongly discouraged in order to maintain clarity, even in cases of renaming or reclassification.
In order to evaluate the clinical effect of the decay in CV risk models, reclassification across CV risk groups before and after correction was calculated.
Category-free net reclassification improvement [ 16] (NRI) was also calculated at various moments (12, 24 and 36 months), in order to evaluate the additional utility of QoL domains and other clinical factors.
In order to illustrate the improvement given by lactate in association with PCT, we provide a reclassification table that enables us to quantify the benefit of the association in terms of number of patients correctly reclassified.
