If species differ more from each other when they co-occur, but are more similar where they do not occur, this suggests that natural selection has favored reciprocal changes within interacting populations (e.g. Schluter and Grant 1982).
The direct regulation of Z by X has the opposite sign as the indirect regulation via Y. GRN (gene regulatory network): A transcriptional network established by the reciprocal regulation of interacting genes.
More generally, it is the idea of some reciprocal evolutionary changes in interacting species.
The significant correlation of the viral and host gene ranks based on the rates of gene evolution further supports the hypothesis of reciprocal evolutionary effects between interacting host and pathogen proteins [ 61].
Coevolution is reciprocal evolutionary change in interacting species driven by natural selection, and is one of the most fundamental ecological and genetic processes that organize earth biodiversity [ 1, 2].
Therefore, it is likely that there is opportunity for reciprocal fitness affects between interacting native and exotic species, though these effects may not be entirely symmetrical, due to differences in both the frequency of interactions and the strength of competitive ability between native and invasive species.
Further consistent with the idea that RTP801 is a substrate for parkin, the two endogenous proteins interacted in reciprocal co-immunoprecipitates of cell lysates.
In summary, structural and kinetic analyses of CH58-UA and mature CH58 showed that a key feature of the paratope, LCDR2, was preconformed for antigen recognition at a site of immune pressure (V2 Lys169) and presented a conserved motif optimal for interacting with a reciprocal motif in gp120 V2.
The Principle of Mutuality determines those "reciprocal tendencies and desires which interact between large bodies of men, aiming at single and definite ends," while the Principle of Dependence has "[n]o man stand[ing] up entirely alone, self-sufficient in the entire circle of human needs" ("Social Principle," 33).
We conclude that FMRP and TIMP pathways interact in a reciprocal, bidirectional manner.
