Moreover, the present confocal and DIC microscopic imaging showed that protein denaturation by pretreatment with protease K or heating blocked the endocytosis of EVs in macrophages, which suggests that protein components in lipid layer of EVs are important for EV endocytosis in recipient cells, in the context of airway immune dysfunction by LPS-induced EVs.
Donor CD8+ T cells are activated when their T-cell receptor (TCR) binds to recipient peptides presented in the context of recipient class I major histocompatibility complex (MHC) molecules (see Box 1 for a glossary of immunological terms).
Instead, the injected DC were short-lived, internalized as apoptotic cells by recipient's quiescent CD11chi DC in the spleen, which presented the donor allopeptides in the context of recipient's MHC molecules to indirect pathway T cells.
However, different laboratories [ 123– 125] have independently shown that the DST effect requires presentation of donor allopeptides in the context of recipient's MHC molecules to anti-donor T cells via the indirect pathway.
We aimed to describe donor and recipient expectations and experiences of their relationship in the context of living kidney donation.
However, cells and genes do not operate independently of their environment, but always in the context of the recipient.
Maintenance of the foreignness of a laterally transferred gene in the context of its recipient genome could reflect either a recent transfer event or a selective pressure to maintain certain features.
But it could not have escaped the senators' attention that two recipients of their letter Jay Clayton and Scott Pruitt had met with Icahn in the context of securing their jobs.
Analysis in the context of donor and recipient (D/R) CMV serostatus showed that, consistent with the established hierarchy of risk, the majority of D+R− patients developed viremia and required treatment (viremia: 58/74, [78%]; treatment: 51/74, [69%]).
Afghanistan is the largest recipient of international aid by some margin, and in the context of a global economic downturn, investments must be justified [ 17].
