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Recently, mechanisms of T-cell mediated graft rejection in old recipients have been examined by Tesar et al. who demonstrated that aged skin graft recipients exhibit an impaired memory T-cell response that is associated with impaired Th1 mechanisms and elevated IL-17 production [10].
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Here we show that PZP recipients exhibited a change in their reproductive schedule: recipient mares gave birth over a broader time period than did non-recipients, with current recipients giving birth later in the year than prior recipient and non-recipient mares.
The results demonstrate that OTI T CD8+ T cells transferred with aged splenic DCs into young recipients exhibited a similar expansion and inflammatory cytokine response as compared to young OTI CD8+ T cells transferred with young splenic DCs into young recipients (Figure 6B C).
Importantly, none of these recipients exhibited GVHD.
Islet recipients exhibited higher fasting glycemia and HbA1c levels than other groups (P < 0.05).
Second, unilaterally nephrectomized recipients exhibited better general conditions than bilaterally nephrectomized recipients after transplantation, particularly in terms of recipient survival.
Overall, 57 (21%) of renal transplant recipients exhibited D-DGF, 103 (39%) exhibited ND-DGF and 106 (40%) exhibited IGF.
The first reported successful transplants to two recipients exhibited good long-term function, with ejection fractions of 56% and 59% 3 months after transplantation [ 28].
At 7 days post-injection (dpi), we confirmed that all of the recipients exhibited EGFP fluorescence at the site of injection (Fig. 3A,D).
Compared with baseline, control and immunosuppressive dendritic cell recipients exhibited a statistically relevant increase in B220+ cells− cells during the dendritic cell administration period (Supplementary Fig. 2).
The frequencies returned to baseline through month 12, although immunosuppressive dendritic cell recipients exhibited lower-than-baseline levels at this time (Table 2).
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