Your English writing platform
Discover LudwigExact(3)
It is based upon homologous recombination between the donor and recipient loci [ 3, 4].
These studies suggest that increased chromosomal mobility facilitates the homology search, which is otherwise restricted by the proximity of donor and recipient loci (Agmon et al. 2013).
Silencer function is required in mating-type interconversion to distinguish donor cassettes from recipient loci through the protection of the HO cut site at HML and HMR, which would seem to have the same requirements as silencing per se.
Similar(57)
This approach is less efficient and prone to induce deletions and other genome rearrangements in the recipient locus, as noted in the first published mouse enhancer trap locus [ 25, 30].
The recipient TLO loci were completely lost in these seven events because the donor TLO was homozygosed at the recipient subtelomere, resulting in a net increase of two copies of the donor TLO.
In B. hermsii, usage frequency is related to the degree of homology between extragenic sequence elements in the donor locus and similar regions in the recipient expression locus [19].
Since the retention frequency of the donor X chromosome is only 5.9% (Additional File 3 Figure S3F), activation of the recipient hamster Xist locus would render the RH clones functionally haploid for most of the X chromosome and would be inviable.
The effect of spatiality is key, since it is the local, resource-mediated interaction between recipient and niche-constructing loci which gives rise to gene linkage.
In each generation, all possible pairs of individuals within each patch meet, and if the actor is homozygous for the cooperative allele and is sufficiently similar to the recipient at the recognition locus, the condition of the recipient is increased by b at a net cost c to the condition of the actor.
Overall, our examination revealed low levels of variability of DNA methylation between donors and recipients at the locus-specific, genome-wide level.
The F1 Arabidopsis hybrids show disparity in the penetrance of TCM and TCdM at different loci, with some recipient alleles completely matching the methylation profile of the donor allele, while at other loci the recipient allele shows only modest changes in methylation.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com