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Repopulation of normal BM cells in recipient livers has been well documented in models of WD [ 13, 14].
The first section was immunostained with anti-FAH antibody to locate the repopulated FAH+ nodules in the recipient livers.
Several technical hurdles must be overcome in order to achieve the therapeutic liver repopulation, such as the problem of insufficient expansion of the transplanted hepatocytes in recipient livers.
Although transplanted hepatocytes have been shown to engraft in recipient livers, and repopulation of up to ∼2% of the liver has been reported, it is not yet clear whether there is any clinical benefit to transplantation.
In comparison with WT hepatocytes, the hepatocytes with FoxM1 expression had an enhanced level of liver repopulation in the recipient livers at both sub-acute injury (fumaryl acetoacetate hydrolase (Fah)–/– mice model) and acute injury (2/3 partial hepatectomy mice model).
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Rejection and hypoxia are the main factors that limit islet engraftment in the recipient liver in the immediate posttransplant period.
In the present case report, hepaticojejunostomy was considered the only option as the common bile duct was donated with a recipient liver for a subsequent domino transplantation.
These kidneys are discarded 2.5 times more often than their HCV-negative (HCV−) counterparts, possibly due to the sense that an HCV+ kidney may adversely affect recipient liver function.
In the paediatric recipient population, for example, it has been shown that transplant of the just the left lateral segment from a living adult donor is sufficient for adequate recipient liver function; however, this is not the case in the adult recipient population [27].
Both cell types were able to proliferate extensively in the recipient liver, as expected.
As expected, both cell types exhibited selective clonal proliferation in the recipient liver.
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