Sentence examples for recipient environment from inspiring English sources

As a consequence, crucial to obtain successful cell replacement and integration in the mature CNS is a deep understanding of the basic biological mechanisms that regulate the interactions between newly added elements and the recipient environment.

Although it is clear that upon transplantation MSC exert most of their therapeutic effects through the secretion of bioactive molecules, the effects of a pro-inflammatory recipient environment on MSC secretome have not been characterized.

After the establishment of an invader, the demographic expansion of the species is independently or interactively affected by multiple biotic factors of the recipient environment [e. g. 6], [7], [8], [9].

For each transition domain, we identified a set of relevant activities, which help to anchor the necessary responsibilities, rules, norms, and structures into the program recipient environment.

However, it is currently unknown how much of an impact the older recipient environment would have on the functionality of younger donor leukocytes.

First, uniform national standards for each pollutant will be underprotective for some ecosystems and overprotective for others, inasmuch as the toxicity of a pollutant to the indigenous biota is dependent on the physicochemical properties of the recipient environment.

Our general approach was to seed adult and old mice with equal numbers of identical adult OT-I TCR transgenic CD8 T cells and to compare their ability to expand in age-disparate recipient environments in response to microbial challenge.

In this way, the CFSE-labeled OT-I CD8 T cells acted as indicator cells to examine the availability of antigen that can prime naïve T cells throughout the first 10 days following Lm-OVA infection in adult and old recipient environments.

Hence, the donor's cells in the recipient's "environment" behave as they do in their own "environment".

These data indicate that aging impairs the recipient host environment (containing APCs) to activate and expand antigen specific CD8+ T cell responses in vivo, although the aged host environment allows effective cytokine responses in these T cells.

Our study has provided evidence that aging impairs the ability of the recipient host environment, both intrinsic and extrinsic to the T cell, to respond to skin transplants.