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In the recessive model comparison, heterogeneity among all studies on the p21 Ser31Arg polymorphism and cancer risk was observed (χ = 98.56, P = 0.0001).
Heterogeneity analysis showed that tumor type contributed to substantial between-study heterogeneity (recessive model comparison: χ = 21.83, df = 7, P = 0.003).
In stratified analysis by tumor type, recessive model comparison with the heterogeneity test showed that individuals with variant homozygous genotypes (31Arg/Arg) had a higher risk for colorectal cancer (OR = 1.39, 95% CI = 1.03 to 1.08, P = 0.25) and estrogen-related cancer (OR = 1.27, 95% CI = 1.01 to 1.60, P = 0.002), but not for other cancers (Table 2).
The strength of association between CYP1A1 polymorphisms and susceptibility to COPD was evaluated by calculating the odds ratio (OR) with corresponding 95% confidence interval (CI) under the following five genetic models: dominant model, recessive model, homozygote comparison, heterozygote comparison, and allele model.
Genotype frequency of the subjects specified by different genetic models (additive, dominant, recessive and homozygote comparison) was analyzed by multivariate logistic regression adjusted for covariates.
Single SNP association analysis revealed that SNP14 (rs7750586) was associated with psychosis, since both the G allele and the G/G genotype were more frequent in the group of patients with schizophrenia (P = 0.001 for the genotypic comparisons (recessive model); see table 1 for the allelic comparisons).
We demonstrated important results in those analyses, since the dominant, recessive, and codominant comparisons showed significant associations between MTRR c.66A>G (rs1801394) polymorphism and maternal risk for DS.
The dominant types of OP are more clinically challenging because of normal life expectancy in comparison with recessive (malignant) forms [1, 3, 17, 35, 36].
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