Seven transmembrane receptors (7TMRs), commonly referred to as G protein-coupled receptors, form a large part of the "druggable" genome.
Belelli, D. et al. Extrasynaptic GABAA receptors: form, pharmacology, and function.
Ngo-Anh, T.J. et al. SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines.
Death receptors form the death-inducing signaling complex (DISC), and recruit initiator caspases, either caspase-8 or -10, followed by the activation of effector caspases15,16,17.
Audette, D. S. et al. Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression.
Recently it has been shown that both receptors form a functional receptor heterocomplex that is altered in schizophrenia.
Many species of receptors form dimers, but how can we use this information to make predictions about signal transduction?
The interaction between HER2 and HER3 underlies many cancers, including glioblastomas, and the results from our group provided the first clear mechanistic insights into how these two receptors form an active signaling complex.
We provided evidence that P2Y4 and P2Y6 receptors form high order complexes in native neuronal phenotypes and that the oligomers can be disaggregated down to the dimeric P2Y4 or to the dimeric and monomeric P2Y6 receptor.
For the last decade, the neurobiologist at Hunter College in New York City has been studying how odorant receptors form on the surface of neurons within the olfactory system.
These transmembrane cell surface ECM receptors form heterodimers composed of an α and β subunits [5].
