Sentence examples for receptors fail from inspiring English sources
Pharmacological studies in various acute and chronic pain models generally support a pro-nociceptive action of PACAP-38, and mice deficient in PACAP and PAC1 receptors fail to develop hypersensitivity to nociceptive stimuli in neuropathic and inflammatory pain paradigms.
Furthermore, we and other workers have now demonstrated that the mutant receptors fail to localise to the cell surface [ 56].
There is little evidence showing that glutamate receptors fail to cluster appropriately in the absence of MAGUKs – a critical prediction of the 'MAGUK scaffold' model.
Consistent with this, where their functional properties have been elucidated, the mutant receptors fail to bind ligand and are devoid of transcriptional activity [13,15,16].
Immobilized UNC-49B receptors fail to undergo diffusional exchange in FRAP experiments and are stabilized by FRM-3 and LIN-2A.
Centrocytes with high affinity B cell receptors are more likely to successfully bind antigen and receive survival signals, while centrocytes with low affinity receptors fail to bind and undergo apoptosis.
Circular dichroism experiments revealed that a dimeric β-cylodextrin receptor synthesized from a [1,1′-biphenyl]-4,4′-dithiol [1,1′-biphenyl]-4,4′-dithiol [1,1′-biphenyl]-4,4′-dithiol [1,1′-biphenyl]-4,4′-dithiolcorel-p-t-butylphenylalanine in the i, i+11-positions, while other demonstratedmonomeric receptors fanled to do so.
B. cereus spores lacking GerI or GerQ receptors failed to germinate in the presence of inosine only.
First, introducing or increasing levels of NR5A receptors failed to recapitulate an ATR response in non-responsive cell lines.
Regarding the latter group, absence of the signal transducer and activator of transcription 1 (Stat 1) results in a signaling defect in which ligand binding to IFN receptors fails to induce the transcription of the >300 IFN-stimulated genes that mediate the 'antiviral state' [51], [52], [53].
In multivariate analysis both nodal status and tumour size were powerful independent prognostic factors, but oestrogen receptors failed to achieve statistical significance.
