DCs express a number of different membrane-bound CTLRs, which can function as pathogenic antigen-recognition and antigen-uptake receptors, internalizing and processing for efficient presentation to effector cells.
Although the putative SP is not required for receptor synthesis, it still plays an important role in receptor synthesis and processing.
Our data clearly exhibit that the SP of GLP-1R is not required for receptor synthesis and processing.
Although most conjugate would be captured by normal hepatocytes following intravenous administration, it was shown that the human hepatoma cell line HepG2 retains the galactose receptor, accumulating and processing the conjugate efficiently.
In the lungs, a number of factors may influence the relative importance of B cells versus other APC in the development of T cell responses: anatomical location, intrinsic antigen uptake and processing ability, receptor specificity, and the availability of antigen.
The present study showed that nematode proteins involved in cellular processes (Table 3, Additional file 2) including endocrine signaling pathways and immune system (such as Toll-like receptors and antigen processing) had 50% more deletions and insertion than those involved in genetic information processing.
However, the poor selectivity of GSIs, which inhibit the proteolysis of all four Notch receptors, and the processing of an expanding list of other substrates by gamma secretase [16], [42], [43], constitute significant potential limitations for this class of anti-tumor agents.
K63 polyubiquitylation is also critical for the activation of additional signaling pathways [23], [24], and has been shown to regulate receptor endocytosis and processing [25], [26], protein sorting in the multivesicular body pathway [27], cell motility [28], cell-cycle checkpoints [29], and autophagy [30].
It is not only able to set a threshold for ATP-induced activation of P2X7 but further provides new ligands for other purinergic receptors by processing ATP, in combination with CD73, to adenosine.
The QTLs also include the genes for cytokines and cytokine receptors, antigen processing and presentation, and hormonal balance.
