Exact(4)
This study suggested that the nanoparticle preparations of selective estrogen receptor modulators deliver the drug in the specific estrogen receptor zone resulting in enhanced therapeutic efficacy.
The chemical senses of smell (olfaction) and taste (gustation) are distinctive among the sensory systems in that environmental sampling and feature detection require activating stimuli to be internalized into the oral and nasal cavities, and chemical moieties associated with stimuli to cross the milieu (mucus or saliva) of the receptor zone.
We found distinctive colocalization pattern between the two signals around the receptor zone at the NMJ (Fig. 5).
The calreticulin-negative gelatinolytic spots located at the acetylcholine receptor zone might represent some kind of exocytotic organelles/vesicles that no longer contain endoplasmic reticulum-resident proteins.
Similar(55)
By overstacking affinity zones, even partially, this configuration creates a "strong" spatial correlation which influences dramatically the complex formation rate: within a cluster of receptors, the occupation of a receptor affinity zone is directly dependent of the occupation of affinity zones of the other receptors, since they are totally or partially the same.
In order to check whether the simulations were reaction-limited or diffusion-limited, we compared the average mean first passage time (MFPT) of a ligand molecule in a receptor affinity zone to the reaction time-scale.
In order to explore the effect of this rebinding, we perform the following experiment: instead of releasing a ligand at the edge of its former cognate receptor affinity zone when it undocks, the ligand is relocated randomly within the entire medium.
Or alternatively, receptor affinity zones could simply be adjacent without overlapping.
Indeed the membrane is not evenly covered and has large receptor-free zones.
Modelling receptor as affinity zones with probabilistic binding allows to directly relate simulation parameters with ODE formalism.
Regarding protein expression of the EP1 and EP2 receptors, the antibody against the EP2 receptor labelled all zones of the epiphyseal growth plate in a homogeneous manner.
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