Sentence examples for receptor trail from inspiring English sources

Like TRAIL, the decoy receptor TRAIL R4 was associated with CD68-positive cells mainly in the synovial lining.

Although a similar trend was observed with the decoy receptor TRAIL R3 the differences were not as marked (Table 2; Figure 1).

The other decoy receptor, TRAIL R4, was expressed in synovial tissues from all forms of arthritis and, to a lesser extent, in normal synovial tissues.

In addition, an agonistic monoclonal antibody that binds to the TRAIL death receptor, TRAIL R2, has been reported to induce apoptosis in RA synovial fibroblasts [ 18, 19].

It is notable that the expression level of TNFRSF10D, which inhibits toll-like receptor (TRAIL) mediated apoptosis, was significantly higher in SNK/T cells.

Some studies have shown that TRAIL and its receptor, TRAIL R2, are expressed in the synovial tissues of RA patients [ 17, 18] and TRAIL R2 is highly expressed in synovial cells in culture [ 18- 21].

Five different receptors interact with TRAIL: TRAIL Receptor-1 (TRAIL-R1/also referred to as DR4), TRAIL Receptor-2 (TRAIL-R2/DR5), TRAIL Receptor-3 (TRAIL-R3/DcR1), TRAIL Receptor-4 (TRAIL-R4/DcR2), and osteoprotegrin (OPG) [ 18, 19].

We observed sTRAIL FeSOD to engage the TRAIL receptors (TRAIL-R1 and TRAIL-R2), resulting in internalization of the receptor and ligand.

Recombinant TRAIL or monoclonal antibodies targeting TRAIL receptors (TRAIL-Rs) are currently being tested in phase I/II clinical trials for patients with advanced tumours.

Koornstra et al (2003) reported that colonic tumours overexpressed the TRAIL receptors TRAIL-R1 and TRAIL-R2 in vivo relative to normal mucosa, but that overall expression of TRAIL receptors was not significantly different between adenomas and carcinomas.

Lexatumumab is a fully human agonistic antibody that specifically binds the death receptor TRAIL-R2, activating the extrinsic apoptotic pathway [20].