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Taken together, our findings are suggestive for fusion activity induced by CDV between infected and target cells, which presumably result from the combination of the fusion complex and a viral receptor, to enable the virulent virus to spread in glial cells.
Similar(59)
We are investigating the interactions of recombinant human IgG antibodies with Fc receptors to enable selection of a constant region giving minimal depletion of antigen-bearing cells.
To address this problem, we have developed the antigen-mediated genetically modified cell amplification (AMEGA) system, which uses chimeric receptors to enable the selective proliferation of gene-transduced cells.
It is the local signal environment that directs the immediate structures, and that environment can change along an axis, as cells stop secreting one kind of signal (or stop producing receptors to enable them to detect it), and start producing other signals.
However, since AAV6 is largely refractory to intravitreal transduction and has a marginal ability to transduce Müller cells subretinally [14], ShH10's novel tropism may then partly result from an improved binding affinity for EGFR (or another co-receptor) to enable Müller cell binding and endocytosis.
Considering a similar functioning of the predicted SpaABC and SpaDEF pilus proteins from C. pseudotuberculosis, either a complete pilus structure or the minor pilins SpaB and SpaE can probably make the initial contact with host cell receptors to enable additional ligand-receptor interactions and to facilitate the efficient delivery of virulence factors and intracellular invasion.
Native ECM as an essential part of stem cell microenvironment provides a structural scaffold to resist tensile and compressive stress and functions as a tight connection to cytoskeleton of cells through cell-surface receptors to enable cells to sense and respond to mechanical and chemical signals [ 24].
Interaction with heparan sulfate is hypothesized to protect growth factors against degradation, to create a storage depot for later release, to facilitate assembly of signaling complexes (co-receptor activity), to enable clearance by endocytosis, and to regulate growth factor diffusion through the tissue [22], [23], [24].
Gβγ reversibly complexes with the α subunit to form a Gαβγ heteromer that associates with G-protein-coupled receptors (GPCRs) to enable transduction of extracellular signals.
The gene expansion observed could provide the diversity of receptors required to enable the animal to recognize diverse water-soluble molecules, as well as complex pheromone blends during the coordination of attraction and reproduction.
Activation of the receptor is necessary to enable persistent synaptic plasticity (Naie and Manahan-Vaughan, 2004; Popkirov and Manahan-Vaughan, 2011) whereby the NMDA receptor preferentially enables induction of plasticity to occur.
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Justyna Jupowicz-Kozak
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