TH expression in PGCs depends on glutamate release by olfactory receptor terminals [40], and reduced synaptic activity following olfactory deprivation is responsible for TH down-regulation [26].
Moreover, nNOS was not present in cough receptor terminals, but was expressed by fine varicose fibers, in the guinea pig trachea.
In either case, it is likely that since the native chest and reinnervating afferents shared space in the skin, there were a reduced number of receptor terminals devoted to either population of afferents.
In the airways, α3 Na+/K+ ATPase is not expressed in substance P-containing C-fibers (Fig 1 of present study; [ 6]) but is present in the peripheral terminals of SARs in rabbits and rats [ 21, 29], myelinated afferent fibers associated with NEBs in rats [ 21] and cough receptor terminals in guinea pigs (Figs 1 and 7 of present study; [ 6, 30]).
For example, overexpression of a functionless TGF-β type II receptor accelerates terminal chondrocyte differentiation [ 40].
We designed nanotraps as artificial decoy receptors based on poly(lactic acid) (PLA) nanoparticles covered by heparin and bearing on the surface two fragments of CCR5 receptor (N-terminal domain, Nt, and second extracellular loop, ECL2), responsible for chemokine binding.
Vallier at al. [14] originally observed abnormal projection morphologies in receptor C-terminal mutants.
None of the filamin constructs or the receptor C-terminal tail supported growth by themselves.
Similarly, olfactory receptor neuron terminals are activated by natural sniffing of deodorized air in the awake rat [24].
Our studies provide a correlation between binding affinity to glycan receptors with terminal alpha 2,6-linked sialic acid and the efficiency of respiratory droplet transmission for pandemic H2N2 influenza viruses.
map this interaction on both partner molecules and reveal a functional role for the receptor N-terminal domain.
