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Once the molecules are aligned a grid or lattice is established which surrounds the set of analogs in potential receptor space.
Conversely, other receptor subtypes (5HT, alpha-adrenergic, beta-adrenergic, and dopamine receptors) cluster together, which hence allow leaving one receptor out while still retaining much information about the receptor space of that particular protein family.
Another sensory system serves to illustrate this difference between receptor space and perceptual space: touch.
Receptor space can then be displayed as a chromaticity diagram with n-1 dimensions.
E. coli projects the 5-dimensional receptor space onto a 1-dimensional perceptual space of attraction/repulsion.
These dynamics shape the chemoreceptor gene complements in Caenorhabditis species and define the receptor space available for chemosensory responses.
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The smallest interparticle spacing, 60 nm, is the minimum receptor spacing as estimated from available data (Supporting Information Figure S3).
Thus, it is conceivable that the real in vivo receptor spacing lies above this 60 nm minimum value.
The calculation of receptor spaces (and their associated chromaticity diagrams) is described in detail by Kelber et al. [ 62].
Simulations were run with diffusion coefficients between 0.01 and 10 (for all the following experiments we used dt = 10-4), still comparing homogeneous receptor spacing and receptor clustering.
Several mutant ligands in the ensemble are expected to bind to the mutant receptors, and then the ensemble may create a defensive wall surrounding the target receptors in receptor-sequence space.
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