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In the case of the mutant receptor, situation was similar after Endo H or PNGase F treatment.
Remarkably, the PBMCs of AIA rats responded to IB-MECA treatment in the same manner as did the synovial cells, namely with receptor downregulation, suggesting that PBMCs reflect the receptor situation in inflammatory tissues and may have utility as a biomarker for monitoring response to IB-MECA [ 12].
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With respect to muscarinic receptors, the situation is not clear.
Given the very large number of possible mediator-receptor combinations, the situation becomes quite complex.
The receptor binding site.
At low population density only basal amounts of diffusible signal molecules are produced, and in this situation the receptor will act as a kinase, resulting in the phosphorylation of the downstream response regulator LuxO through a cascade involving LuxU [5].
The fact that stereotypical CLL BCRs recognize autoantigens in stromal cells [ 84] is an example of a situation where receptor editing could be in a position to try to avoid autoimmunity in a definite microenvironment.
In conclusion, we showed that the communication range of vibrational signals is not limited by substrate continuity and that in this situation antennal receptors are not essential in detection of vibrational mating signals.
Thus, in contrast to V1Rs, where a correlation exists between the size of this receptor group and adaptive situations (Wang et al. 2010), the functional significance of the expansion or loss of V2Rs in mammalian species is not clearly established.
It resembles the real-world situation of deorphanizing receptors where information from related proteins of the 'orphan receptor' is taken into account to identify bioactive chemical matter for a receptor for which no ligands have been identified yet [55, 56].
Receptor receptor contacts could be limited to a signalling dimer or lead to the formation of receptor clusters, similarly to the situation with Eph RTKs [67,68].
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