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Vascular alpha 1-adrenergic receptor responsiveness, assessed by pressor response to phenylephrine, was unrelated to blood pressure, but was significantly greater in black than in white men.
The exposure of chemokine receptors to high concentrations of chemokines often results in the rapid attenuation of receptor responsiveness and a reduced biological response.
Its effects likely resulted from an increase in receptor responsiveness, because it revealed functional 5-HT2A5-HT2Areceptor-operatedreceptor-operatedrons, an effect mimicked by knockdown of PSD-95.
However, an adequate receptor responsiveness is necessary to allow intracellular signalling and metabolic activity.
Taken together, these findings reveal that post-pubertal NVH lesioned rats display enhanced muscarinic receptor responsiveness, which may relate to some behavioral abnormalities reported in this animal model.
One of several potential reasons for the facilitatory D1 effect is the enhancement of postsynaptic glutamate receptor responsiveness, in particular those mediated by N-methyl-D-aspartate (NMDA) receptors (Cepeda et al, 1993; Umemiya and Raymond, 1997).
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The oestrogen receptors responsiveness in aggressive fibromatosis tumours has been thought to be responsible for a predominance of this tumour type in females.
Previous studies have described desensitization of P2Y2-receptor responses in several cell backgrounds, however, few studies have addressed the regulation of native P2Y2-receptor responsiveness and none to our knowledge have done so in mesenteric arteries.
However, the cardiovascular and cGMP responses to these hormones are markedly attenuated, indicating impaired receptor or post-receptor responsiveness of GC-A [ 25, 26].
Wencker, M. et al. Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.
Therefore, other (minor) mechanisms may yet be shown to be involved in regulating P2Y2-receptor responsiveness in MSMCs.
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