These finding suggest that a reduction of postsynaptic AMPA receptor responses and an increase of Glu2A/2B ratio are the mechanism responsible for the impaired hippocampal LTP that was induced by CSD.
Injury, sepsis, and the regulation of Toll-like receptor responses.
Hinz, M. & Scheidereit, C. Striking back at the activator: how IκB kinase terminates antigen receptor responses.
Model of honey bee receptor responses and resulting antennal lobe (AL) activity.
Positive allosteric modulators might be advantageous, since they facilitate receptor responses without directly interacting with the agonist binding site.
Chloramphenicol: The most severely affected receptor responses upon chloramphenicol application were seen for the constructs ggTas2r1K86A and -N93A, with clear shifts of the dose-response towards higher concentrations as well as reduced maximal signal amplitudes.
Receptor responses could be fit by a simple "two-state" model in which receptor dimers are in either active or inactive conformations, from which energy bias and dissociation constants could be estimated.
They also participate in the coupling between the plasma membrane and the actin cytoskeleton, which regulates immune receptor responses in T cells, B cells, and mast cells, both positively and negatively, depending on the cellular context.
Following incubation with the MEK 1/2 specific inhibitor SB408039 or the raf inhibitor SB386023b the up-regulation was attenuated both for ETB receptor responses and in ETB receptor mRNA expression in the vessel segments.
These results could help to understand the biophysical mechanism of HA in regulating CD44-induced physiological activities and thus facilitate the new design of HA-based material in fine tuning the receptor responses.
In contrast, postsynaptic N-methyl-D-aspartate (NMDA) receptor responses remained unchanged.
