Sentence examples for receptor residence from inspiring English sources

Structure kinetic relationships (SKR) opened up the possibility of long receptor residence times.

Investigations like this may prove to be useful to qualitatively predict differences in receptor residence times for structurally closely related ligands.

The fast dissociating antagonist 6 had a similar receptor residence time (RT) as rimonabant, i.e. 19 and 14 min, respectively, while the slowest dissociating antagonist (9) had a very long RT of 2222 min, i.e. pseudo-irreversible dissociation kinetics.

The receptor residence times in the PM and in the RC are much shorter (minutes) than the lifetime of the receptors before they are biochemically degraded (hours, [2]).

The effect of the recycling proper (return to the PM), although it is delayed because of the long receptor residence time in the RC, is to enhance the gradient for the migration of the interface by transporting more receptors to the area next to the RC, which means closer to the advancing interface boundary.

The calculation of actual receptor residence times is usually technically difficult when classic binding techniques are used, because of the high potential for rebinding of labeled ligand to the receptor during dissociation from the receptor (from the medium or lipid biophase; refs. 43 – 43).

They produce valuable results at both spatio-temporal microscopic scale - e.g. first-time encounter probability, ligand-receptor residence time, average distance travelled between rebinding events distributions - and macroscopic scale, such as receptor occupation at equilibrium, or pharmacodynamic dose-response.

Because the spatial and temporal dynamics of cold receptor cell-surface residence may determine neuronal activity, we hypothesized that the movement of TRPM8 to and from the PM might be a regulated process.

These differences relate to lipophilicity, volume of distribution, bioavailability, biotransformation, plasma half-life, receptor affinity and residence time, as well as elimination [ 70, 71].

We also provide evidence that simultaneous monitoring of the 2 diffusing species detected with a fluorescent antagonist can yield insights into receptor allosterism, ligand residence time, and dimerization in small membrane microdomains.

Translocation is anticipated for receptor-mediated cargoes due to interactions between the FG-repeats and the transport receptors, which increases the residence time and probability of entry into the NPC.