Sentence examples for receptor orientation from inspiring English sources

Although this change in type I receptor orientation may seem small, it might nevertheless contribute to a different signaling output for both factors.

The Venus-tagged receptor orientation resulted in a very low ligand-induced BRET signal for the mutant compared to either wild-type OX receptor subtype.

In contrast, the Rluc8-tagged receptor orientation resulted in substantially greater BRET signals between the OX1ctOX2 mutant and both β-arrestin1 and 2. Interestingly, this OX1ctOX2 mutant displays similar kinetics to OX1 receptor, its profile being less stable over the 4 h measurement period compared to that of OX2 receptor.

From this comparison we determined that the membrane-distal part of the BMPR-IA molecules swiveled towards the N-terminal end of the GDF-5 R57A α-helix and further into the concave wrist epitope, whereas the membrane-proximal half of the receptor swung out of the binding site compared to the receptor orientation observed for the BMP-2 BMPR-IA complex.

Both receptor orientations are observed in the images, and the outward-pointing cytoplasmic tips dominate as expected.

Molecular dynamics simulation studies of 11 in three opioid receptors indicated orientation of the 6′-nitro group varied significantly in the different 'address' domains of the receptors and played a crucial role in the observed binding affinities and selectivity.

Since many allergens exist in nature as homodimers, which greatly augments their ability to activate cells with IgE receptors, the orientation of the dimerization could also be an important structural determinant of the relative potency of different allergens.

Given the results that nondesensitizable receptors mediate cell orientation and migration in single ligand gradients at a higher level, we further test the influence of receptor desensitization on gradient sensing and migration in competing ligand gradients.

The α- and β-subunits of the T-cell receptor (in both orientations) cleaved highly efficiently, assembled and were localised to the plasma membrane [ 13].

For optimal development a special composition of extracellular matrix including related cell receptors maintains correct orientation of the CD ampulla to neighboring mesenchymal stem/progenitor cells [ 24].

This architectural variance might provide a possible mechanism for ligand-specific signals even when using overlapping sets of receptors if the orientation difference can be transmitted across the membrane.