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FLNa has also been shown to affect transferrin receptor late endosome or lysosome targeting [30].
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This suggests that the transport of AMPA receptors late in the endocytic pathway is normal in Vac14 −/− neurons.
Furthermore, cytofluorometric analysis showed that treatment with AgNPs reduced the percentage of cells expressing the collagen receptor very late antigen 2, α2β1 integrin (VLA-2) and the laminin receptor very late antigen 6, α6β1 integrin (VLA-6).
In addition, this concentration of drug had no effect on the transport of the mannose 6-phosphate receptor from late endosomes to the trans-Golgi network using a system that reconstitutes this transport process in cell extracts.
Future work is needed to determine if AMPA receptor trafficking late in the endocytic pathway is affected if the PIKfyve/VAC14/FIG4 pathway is inhibited further.
The results demonstrated that the Equisetum extract investigated has little impact on the expression of the IL-2 receptor at late time points at high (0.8 μg/mL: 90% ± 14) concentrations only.
Vps8 is a component of the CORVET complex required for CPY sorting receptor from late endosome to vacuole and Stp22p is a component of the ESCRT-1 complex in the MVB pathway (discussed above).
Aß: amyloid-ß peptide; AD: Alzheimer's disease; apoE: apolipoprotein E; APP: amyloid precursor protein; BBB: blood brain barrier; CNS: central nervous system; EOAD: early onset Alzheimer's disease; LDL: low-density lipoprotein; LDLR: LDL receptor; LOAD: late onset Alzheimer's disease; LRP LDLL receptor-related protein; PS: presenilin; VLDLR: VLDL receptor.
TIP47 facilitates the recycling of the mannose-6-phosphate receptor from late endosomes to the trans-Golgi network by forming a ternary complex with the receptor and Rab9 (Carroll et al. 2001), but the question as to whether the function is related to its presence in the LD has not been addressed.
Thus, phage particles containing a single-strand DNA genome rich in CpG motifs delivered via DEC-205 are able to intercept and trigger the active TLR9 innate immune receptor into late endosome/lysosomes and to enhance the immunogenicity of the displayed antigenic determinants.
The triggering of apoptosis is mediated by early overexpression of members of death receptors and late overexpression of the death receptor ligands.
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