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The structural results, combined with the functional studies on the full-length receptor, form a powerful platform for the design of new selective agonists.
In [Mn(L2)]2+ the metal ion is also placed in the crown hole, but as a result of the large size of the macrocyclic cavity only six of the eight available donor atoms of the receptor form part of the Mn II) coordination sphere, with the Mn II) ion found in a distorted octahedral coordination environment.
In response to G-CSF, mono-/polyubiquitination was impaired in cells transiently expressing the mutant receptor form.
A complex comprising all three subunits binds IL-2 with high affinity and is the receptor form found on activated T cells and Tregs.
Although the Y729F receptor mutant exhibited a trend suggesting accelerated internalization compared to the WT receptor form, this was found to be not statistically significant (p = 0.37).
Our data support a model in which the solubilized ETR1 receptor protein complex contains a receptor homodimer as the predominant receptor form.
Similar(32)
VEGF binds to its receptors (VEGFR2) which are expressed on endothelial cells, producing active phosphorylated receptor forms.
However, increasing experimental evidence suggests that the GABAB receptor forms oligomers larger than heterodimers.
The dimerization of the new receptor forms a hydrogen-bonded capsule.
In addition, we can expect that a new terminology will be proposed for receptor forms and interactions [233, 234].
The results of FT-IR analyses manifested that the boron atom of TMDGB anion receptor forms the complex with ClO4− anions.
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