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A second EGF receptor feedback negative regulator identified in Drosophila is the leucine-rich repeat (LRR) protein kekkon-1 (Kek1).
CTGF: Connective tissue growth factor; DMC: Differentially methylated CpG; DMR: Differentially methylated regions; ERRFI1: ERBB receptor feedback inhibitor 1; LDLR: Low-density lipoprotein receptor.
For example, the ERBB receptor feedback inhibitor 1 (ERRFI1) promoter region harbors a DMR in the shore region of the promoter-associated CpG island.
It is further of note that LPA induced a very robust upregulation of Mig-6 also known as Errfi1 (ErbB receptor feedback inhibitor 1; ~60-fold induction after 2 h).
HER2 tumours exhibited a protein protein interaction network centred on avian erythroblastic leukaemia viral oncogene homologue 2 (epidermalpidermal growth factor receptor and platelet-derived growth factor receptor α, and they displayed enhanced tyrosine phosphorylation of ERBB receptor feedback inhibitor 1.
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We have initiated a survey of the potential for glutamate to exert, via glutamate receptors, feedback on its own export from microglia.
Their cholesterol work has elucidated receptor-mediated endocytosis, recycling of membrane receptors, and feedback regulation of receptors.
(2013) ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
This study examined the role of phasic pulmonary stretch receptor (PSR) feedback in ventilatory control, breath clustering and breath timing in decerebrate, paralysed and artificially-ventilated cane toads (Bufo marinus) under conditions designed to minimise tonic PSR feedback.
Miller, Miles A., Aaron S. Meyer, Michael T. Beste, Zainab Lasisi, Sonika Reddy, Karen W. Jeng, Chia-Hung Chen, Jongyoon Han, Keith Isaacson, Linda G. Griffith et al. "ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling". Proc Natl Acad Sci U S A 110, no.
In activated naïve T cells, IFN-γ induces the central Th1 transcription factor T-bet, while T-bet induces the expression of IFN-γ, in a positive, T cell receptor dependent feedback loop polarizing the T cell into Th1 differentiation.
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