Sentence examples for receptor environment from inspiring English sources

This global increase in primary inflammatory cytokine signalling suggests a tightly regulated cytokine-cytokine receptor environment within the FGT.

The effect of change in dietary fatty acids was assessed by using the data on plasma fatty acids profile which is reflective of dietary intake and reflects the receptor environment.

TFE is also thought to mimic a protein receptor environment by stabilizing helices in regions with intrinsic α-helical propensity that are likely to form helices when binding to their protein partner.

To help focus RISCS research and aid communication of the results, a set of reference terrestrial and marine European receptor environments and associated impact scenario descriptions were defined systematically by evidence-based expert elicitation.

Specifically, we used an explicit atomistic representation of the receptor and its environment, and sampled the conformational transition from the crystal structure of a photoactivated deprotonated state of rhodopsin to the low pH crystal structure of opsin in the presence of 11-trans-retinal, using adiabatic biased molecular dynamics simulations.

These results indicate that HAssLG nanoparticles are responsive to both the CD44 receptor and redox environment.

In the bone environment, receptor activator of nuclear factor- κB ligand (RANKL) is an essential determinant of osteoclast differentiation and activity.

We have demonstrated that properties of either the receptor or its environment that are remote from the ligand-binding site may significantly affect the apparent affinity of a receptor for a competitive antagonist.

The actions of TSEC within a given cell type may also reflect the net effect of TSECs on both receptor and cell environment integrated at the level of gene expression (for example, estrogens may modify the activity or expression of a cofactor that could promote SERM activity and vice versa) [ 96].

This study is particularly provocative as the model suggested targeting the kinase-dead ErbB3 rather than a mutated or overexpressed protein, indicating that excessive growth may be dependent on the multivariate receptor and ligand environment rather than a single oncogenic change.

Thus, contrary to experiments with the DO11.10 TCR transgenic mouse, whereby a Th1-derived TCR can be skewed to mediate either Th1 or Th2 effector functions [ 21], in a physiological polarizing environment, receptor features may be preferentially selected so as to skew the future memory response for an appropriate cytokine profile [ 22].