Whitty, A. et al. Interaction affinity between cytokine receptor components on the cell surface.
The binding of the virus with host cell receptor components is critical for infection.
Co-localization of CGRP and the receptor components was rarely found.
Glial cells also contain the CGRP receptor components but not CGRP.
Despite extensive genetic studies demonstrating the importance of these receptor components in embryonic patterning and cancer, the mechanism by which Ptc regulates Smo is not understood.
Type I interferons activate cellular responses by forming a ternary complex with two receptor components, IFNAR1 and IFNAR2.
Adult rat-derived hippocampal progenitor cells express many of the molecules implicated in midbrain dopaminergic determination, including FGF receptors 1, 2 and 3, the sonic hedgehog receptor components Smo and Ptc, and the region-specific transcription factors Ptx3 and Nurr1.
Collectively, the favorable entropy of the bimolecular interactions appears to be offset by the loss in rigid body entropy of the receptor components in the higher-order complexes, but overcome by the formation of increasingly enthalpically favorable composite interfaces.
Experimental systems, from both avian and murine models of B cell development, have been designed to identify the function of individual receptor components in B cell development.
The magnification shows a neuron immunopositive for both receptor components.
We also evaluated the distribution of the CGRP receptor components using immunohistochemistry.
