Sentence examples for receptor clearance from inspiring English sources

The authors concluded that since the bulkiness of NESP lowers its affinity for the erythropoietin receptor, clearance (i.e., in vivo potency) was the primary determinant for the higher magnitude in efficacy.

Since we observed reduced levels of soluble apoE in Aβ12-28P-treated Aβ12-28P-treated Aβ12-28P-treatedment with APP/E2E/andinhibitor mAPP/E4itionally facilitate Aβ clearance by reducing the levels of apoE comiceing witheAβ for treatmentreceptor clearance pathwith

As a result of defective cell-surface LDL receptors, clearance of LDL from plasma is reduced leading to increased plasma levels of LDL cholesterol and total cholesterol [1].

CVVH achieved significantly greater IL-1 receptor antagonist clearance compared with CVVHD (P = 0.0003).

A novel recombinant human growth hormone (rhGH) fusion protein (VRS-317) was designed to minimize receptor-mediated clearance through a reduction in receptor binding without mutations to rhGH by genetically fusing with XTEN amino acid sequences to the N-terminus and the C-terminus of the native hGH sequence.

This Fc receptor-mediated clearance can be reduced by further immunosuppression with either IVIG or the anti-IL2 receptor antibody, anti-CD122, or by direct injection into the bone marrow.

Thus, Apoe is epistatic to Sec24a, suggesting that SEC24A may regulate cholesterol metabolism via the receptor-mediated clearance pathway.

Older immunised animals also showed Aβ-containing cells with an activated microglial phenotype, suggestive of Fc receptor-mediated clearance of Aβ42.

This includes not only receptor-mediated clearance of endotoxins, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens.

Receptor-mediated clearance is an unlikely explanation because the levels of TrkB are low and p75 high in AD cases when compared with controls (30, 31, 42).

This finding points to an important role of apoE for the development of CAA because apoE4 is less effective in the receptor-mediated clearance of Aβ when compared to apoE3 [ 19].