Sentence examples for receptor box from inspiring English sources

The original carboxy-terminus is replaced with a 33-residue extension containing the nuclear receptor box motif (LxxLL).

Detailed analysis revealed three conserved LXXLL motifs (nuclear receptor box) in the receptor-interacting domain, which appear to contribute to the specificity of coactivator receptor interaction.

This decision is based on the atypical motif for N-glycosylation site (MOD_N-GLC_2) and the nuclear receptor box motif, which confers binding to nuclear receptors (LIG_NRBOX).

A report that the AhR/ARNT heterodimer directly associates with oestrogen receptor- α and - β is interesting in light of our identification of an LXXLL motif or nuclear receptor box in the N-terminus of the PASD1 protein that might mediate similar interactions (McInerney et al, 1998).

Their hyperactivation has been implicated in several diseases, in particular in the development of cancer.[ 417] Coactivator proteins bind the receptor through a so-called nuclear receptor box (NR-box) consisting of a LXXLL motif which adopts an α-helical secondary structure upon binding.

But the nicotine receptors in the brain and muscles are nearly identical--nicotine has a positive charge, and both receptors' boxes have a negative charge.

Sequence analysis in goose indicated high conservation of the three subsections of the TIR domain (boxes 1, 2, 3) known to be important in signaling (boxes 1 and 2) and receptor localization (box 3) [ 24, 25].

What the lysine does, Dougherty and colleagues report online this week in Nature, is change the shape of the brain receptor's box, effectively making its negative charge more accessible to nicotine--a situation known as a cation-pi interaction.

An LXXLL motif or nuclear receptor (NR) box was also detected in the N-terminus of the PASD1 protein between aa 77 81.

Each surface receptor and box in Figure 5 is represented by a node in the leftmost column in Figure 7. Nodes 1 to 3 in the column correspond to the three surface receptors, that is, cell-cell contact, RTK, and integrin, respectively.

Default parameters for the induced fit docking workflow were used, using the bound linezolid molecule as ligand for the definition of the receptor site (box size of 40 Å around the ligand) and refinement of the receptor/pose complex including residues with 5 Å of the ligand.