Sentence examples for receptor agonistic from inspiring English sources
Fenoldopam is a selective dopamine-1 receptor agonist with no β-1 or α-adrenergic receptor agonistic effects and similar to dopamine, it increases renal plasma flow with no effects on GFR, as demonstrated in healthy volunteers [ 25].
Agomelatine is a novel antidepressant drug with melatonin receptor agonistic and serotonin 5-HT2C antagonistic properties.
The free OH and NH functions are found to be essential for β3-adrenergic receptor agonistic activity.
The synthesized compounds were evaluated for their UII receptor agonistic activities using a cell-based assay (R-SAT).
Prompted by this imidazo[1,2-α]pyridine analogues were synthesized and evaluated for their adenosine A1 and A2A receptor affinity via radioligand binding studies and subjected to a GTP shift assay to determine its adenosine A1 receptor agonistic or antagonistic functionality.
In search of potent β3-adrenergic receptor agonists, a series of novel substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes has been synthesized and evaluated for their β3-adrenergic receptor agonistic activity (ranging from −17.73% to 90.64% inhibition at 10 μM) using well established Human SK-N-MC neuroblastoma cells model.
The observed effect could be due to adrenergic ß2-receptor agonistic and/or direct action on the heart.
These likely involve antagonism of isoflurane with NMDA receptors, agonistic actions on GABA(A) receptors and activation of the two-pore potassium channels.
On the other hand, cyclin D1 may induce the tumorigenesis in certain types of cancers by means of its nuclear receptor-agonistic activity in the CDK-independent way [ 52, 76].
In a more recent study, Zhou et al. [ 93] showed that injection of angiotensin-II type I receptor-agonistic autoantibodies induced pre-eclampsia-like features in mice and the inhibition of IL-6 in these mice inhibited these signs.
We previously reported that bis-phenol derivatives, including LG190178 (3a), possess not only vitamin D receptor (VDR) agonistic activity, but also androgen receptor (AR) antagonistic activity.
