An excerpt: The United States Soccer Federation announced a new policy recently that will uncouple high school soccer and the training of top youth players, a move that is unique among major team sports in this country and, some believe, is indicative of a trend in the way the United States develops elite athletes.
The United States Soccer Federation announced a new policy recently that will uncouple high school soccer and the training of top youth players, a move that is unique among major team sports in this country and, some believe, is indicative of a trend in the way the United States develops elite athletes.
Recently, eNOS uncoupling was shown to participate in endothelial dysfunction in diabetic mice [ 23] and to mediate peripheral neuropathy in diabetic rats [ 24].
Thus, it seems possible that both hypotheses are true; this implies that inflammation and new bone formation in AS are not completely uncoupled in AS, as recently proposed [ 37], but are at least partially linked.
We have recently discovered that eNOS can be uncoupled, regardless of the presence or absence of BH4, by S-glutathionylation of critical Cys residues, in particular Cys 689 and Cys 908 of the reductase domain.
We recently determined that the GPR54 mutant, R331X, is uncoupled from this pathway because it is not expressed at the plasma membrane [4].
We have previously developed VavNULL mice as a model in which ITAM signaling is uncoupled from GPCR-induced chemokine signals, and we recently showed that Vav is required for activation of Rac downstream of integrin-mediated ITAM signals, but not GPCR-mediated signals [7], [8], [9].
Thus, reduced hippo signaling and pS127-YAP levels appear effectively uncoupled from automatic nuclear localization, in keeping with the recently demonstrated requirement for tyrosine phosphorylation to mediate the transition [ 29].
However, this spare cII activity that was recently observed remains unutilized under normal conditions, but becomes manifest when oxygen consumption is uncoupled from ATP production, or if there is an increase in energy demand.
However, Grandison et al. [16] very recently demonstrated that high fecundity and longevity are not mutually exclusive and can actually be uncoupled in D. melanogaster by methionine supplementation during caloric restriction.
This model was recently challenged by Van Keymeulen and colleagues, who suggested that the basal and luminal lineages were uncoupled in the adult mammary epithelium and that each lineage contained a unipotent stem cell population [ 6].
