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In these circumstances, a deviation of the female male MRR from 1.0 for children who have received a specific vaccine as the most recent vaccination would suggest that this vaccine is associated with sex-differential NSE.
We furthermore hypothesised that the lower dose would be particularly beneficial in girls who had DTP vaccine at their most recent vaccination contact compared with girls who had other vaccines.
The effect of VAS differed by most recent vaccination, being beneficial after measles vaccine but not after diphtheria tetanus pertussis vaccine.
RV was found in seven specimens from the children who were known to have received RV vaccines; of these, three were vaccine-type viruses from recent vaccination.
After 6 months of follow-up, the MRR was 0.60 (0.14-2.50) if the most recent vaccination was DTP and 3.06 (0.63-15) if the most recent vaccine was BCG vaccine or measles vaccine (p for same effect = 0.12).
In addition we tested whether recent vaccination with seasonal trivalent inactivated vaccine (TIV) induced cross-reactive antibodies to pH1N1.
Furthermore, we conducted two randomised trials reducing the time of exposure to DTP as most recent vaccination by providing a live vaccine shortly after DTP.
However, the NSE of vaccines apparently influence general susceptibility to infectious diseases and that effect seems to be strongest while a vaccine is the most recent vaccination.
However, both studies suggest that it is beneficial to reduce exposure to DTP as most recent vaccination by using a live vaccine.
The authors reduced exposure to DTP as most recent vaccination by administering a live vaccine (MV and BCG) shortly after DTP.
We have previously observed that girls benefit more from a lower dose of VAS than the one recommended by WHO, the effect being strongest if diphtheria-tetanus-pertussis vaccine (DTP) was the most recent vaccination.
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