Alternatively, data consisting of landmark coordinates analyzed using geometric morphometric methods are in widespread and increasing use in the recent literature on human variation (e.g., (Ackermann 2005; González-José et al. 2008a,b; Harvati et al. 2004; Harvati and Weaver 2006; Perez et al. 2007, 2009)).
I've focused this review on technical details because I think that it's important that non-geneticists understand how Wade is distorting the results of recent research on genome-wide human variation.
This statistic is significantly predictive of recombination rate, shows additional regional and population-specific conservation, and allows us to identify outlier genes likely to have experienced unusual amounts of variation in recent human history.
Recent human microsatellite studies suggest that multi-step variation is a significant component of variation at larger SSR loci [ 25], deviating from the SSM model.
Some results from the human 1,000 Genomes Project indicate that classical selective sweeps are rare in recent human evolution but in fact the selection on standing variation is more common [ 22].
Here, we describe the results of recent human and animal intervention studies and discuss factors that might explain the variation in results.
Previous analyses of genome-wide variation patterns have provided support for the "out-of-Africa" hypothesis of recent human evolution (Jakobsson et al. 2008; Li et al. 2008).
This is the first record, to our knowledge, of parallel selection acting on standing genetic variation in humans and suggests, as others have observed [10], that this may not be uncommon in recent human adaptive history.
Rather, we should encourage human enhancements that amplify human variation.
The most striking instances of recent human evolution have emerged from a new kind of study, one in which the genome is scanned for evidence of selective pressures by looking at a few hundred thousand specific sites where variation is common.
