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Verhovsek et al. [ 22] found that residents receiving interacting medications spent less time in therapeutic range.
Residents receiving interacting medications spent less time in the therapeutic range (53.0% vs. 58.2%, OR = 0.93, 95% confidence interval 0.88 to 0.97, P = 0.002).
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Of new statin users, 2430 (13.5%) received interacting drugs during the follow-up period.
Among 2430 patients (13.5%) received interacting drugs with statins, only three muscle toxicity cases were observed (incidence: 1.69/1000 person-years).
While listed here separately, the power of PBPK is its ability to predict realistically complex scenarios that often arise in clinical practice, such as patients with multiple pathologies and comorbidities who may be receiving several interacting drugs, some of which exhibit genetic polymorphism in one or more metabolic or transporter processes.
Despite monitoring, TTR was lower in residents receiving warfarin-interacting medications.
Residents receiving warfarin-interacting medications during the period of the chart audit had a TTR of 53.0%, compared with a TTR of 58.2% in the residents on no interacting drugs (OR = 0.93, 95% CI, 0.88 to 0.97, P = 0.002).
We also assessed subjects' social support, which is received by interacting with others.
In-person observations were also conducted at 4 CMHCs, including home visits by researchers (n = 15 patients) prior to the CMHC visit and observations of patients receiving injections and interacting with staff.
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