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Half of patients receiving high risk medications do so for less than a year.
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28 This concern arises from the observation that diseases considered to have a genetic basis are perceived as less controllable, 29 and as such genetic risk assessments may engender a fatalistic response in those receiving higher risk estimates or readily provide false reassurance in those receiving lower risk estimates.
We regarded a trial as having: low risk of detection bias if they were blind to knowledge about which intervention the participants received; high risk of bias if blinding was absent; and unclear risk if blinding was not clearly described.
As a tertiary and a referral hospital for the four regions in the Northern part of the country, the NCU at KCMC receives high risk babies delivered within the institution and referrals from other health facilities or from home.
Three studies [ 43- 45] received high risk of bias ratings for the administration of the index test due to not having a pre-specified threshold score, which may result in an over-estimation of test performance due to over-fitting [ 35].
Being a major referral centre and the only tertiary health facility in the middle sector of the country, the hospital receives high risk obstetric referrals which inevitably lead to increased adverse pregnancy outcomes, thus explaining our much higher proportion of stillbirths compared to the national estimate.
In subjects receiving high-risk antibiotics, recurrence tended to be less frequent (by ≥5%) following fidaxomicin than vancomycin treatment, but none of the differences was significant.
(GP interview 1) All GPs interviewed highly valued the process of reviewing patients identified as receiving high-risk NSAID or antiplatelet prescriptions.
The median-treatment duration for patients commencing single-agent but changing to multi-agent chemotherapy was 13 days more than those receiving high-risk treatment alone (136 vs 123 days; P=0.07).
Among patients receiving high-risk chemotherapy regimens, patients with breast cancer were significantly more likely to receive G-CSF as primary prophylaxis than patients with non small-cell lunon small-cellNSClung
Day 1 lymphopenia identifies a small subgroup of patients at risk for FN among patients receiving high-risk regimens, but is much less sensitive than day 5 lymphopenia in all series tested.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com