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A second possibility is that some epithelial gene expression changes are secondary to altered stromal signaling because the UE is plastic and receives instructive signals from the UM at this stage of development (Cunha, 1976).
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Shaman have, for centuries, concocted ayahuasca brews containing the so-called "spirit molecule" to summon otherworldly beings and receive instructive messages from another realm.
Despite the clear-cut action of GCs on PC axon phenotype, in the pure E17 cultures many PCs spontaneously engage into arbor formation, implying that they had already received instructive information at the time of dissociation.
Patients also received instructive training in ankle motion and balance/proprioception.
This suggests that the Acvr1 R206H mutation is not required in precursor cells, and that wild-type precursor cells can receive instructive signals in a cell non-autonomous manner to guide their differentiation through an endochondral pathway (Chakkalakal et al., 2012).
The comments he received were instructive.
The authors said they had received an instructive lesson in the frequent unreliability of the very eyewitness identifications juries so often find persuasive.
Observations were done at least six times a year, and new teachers were critiqued rigorously, yet the feedback received was reasonable, instructive and intended to help us develop the skills necessary to thrive in an inner-city school.
In Victorian magazines, "Shy Violet" would write in about whether to wait for the suitor she loved or make a sensible marriage with the one her parents had approved, and receive stern, morally instructive replies: "Do not let youthful foolishness obscure your mother's good sense".
The terror of receiving such uninhibited (and instructive) commentary from complete strangers enthralls her.
In many cases, this is dependent on positional information, where the relative position of a cell within the embryo determines the nature or amount of instructive differentiation signals received.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com