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Clin = group of infants from Malaysia and Singapore who received the Phase III Clinical lot of PHiD-CV in the primary vaccination phase.
There were no confirmed PDVFs (HIV-1 RNA ≥400 copies/ml) in participants who received the phase III-selected dose (DTG 50 mg).
Similarly, in the phase I/II trial of bevacizumab combined with erlotinib (Herbst et al. 2005), 9% of patients who received the phase II dose of bevacizumab (15 mg/kg) developed proteinuria.
In conclusion, once-daily DTG with two NRTIs was efficacious through 96 weeks at all doses studied, with 88% of participants who received the phase III-selected dose of 50 mg achieving plasma HIV-1 RNA less than 50 copies/ml.
Non-inferiority of the immunogenicity of the PHiD-CV Commercial versus the Phase III Clinical lot was demonstrated for each vaccine pneumococcal serotype and protein D, although antibody GMCs for serotypes 4 and 5 and protein D, and OPA GMTs for serotype 18C, seemed higher in infants who received the Phase III Clinical lot.
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Pharmacokinetic studies were performed in 17 patients receiving the phase I portion from 60P to 80P (Table 3).
In the primary vaccination phase, 298 infants from Singapore and 168 infants from Malaysia were randomised to receive the Phase III Clinical (Clin) or the Commercial (Com) lot of PHiD-CV at 2, 3, and 5 months of age.
Notably, compared with patients with non-squamous NSCLC, patients with squamous NSCLC exhibited greater improvements in irPFS and OS over chemotherapy alone upon receiving the phased-schedule ipilimumab/chemotherapy regimen [ 80].
After its funding two years ago, Locately won Small Business Innovation Research SBIRR) Phase I and II grants from the National Science Foundation, and received the START Phase I award from MassVentures, the VC arm of the Commonwealth of Massachusetts.
However, the rats now received the sample phase in one maze (e.g., Maze A) and the choice phase in the other maze (e.g., Maze B).
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