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Twelve participants (7%) received step 4 (pregabaline).
NRs at step 1 who had PND and phlegm received step 2-a treatments.
Thirty one participants (18%) received step 3 (buprenorphine transdermal patch), and in addition eight participants (5%) the dosage was increased.
Four participants (2%) received step 2 (three started with morphine; in one patient the primary prescription was adjusted).
In the intervention group, 111 (63%) participants received step 1 (paracetamol 3 g/day) of the treatment protocol, and in addition nine patients (5%) an existing low dosage was increased.
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Seventeen women underwent laparoscopic ovarian multi-needle intervention (LOMNI), and 18 women received step-up ovulation induction treatment with recombinant follicle-stimulating hormone followed by intrauterine insemination for three cycles.
Among the 216 patients in the safety population, 151 (69.9%) received anidulafungin only; 49 (22.7%) and 16 (7.4%) also received step-down therapy with fluconazole or voriconazole, respectively.
Almost half the patients received stepped care when indicated.
Participants in the VADT (n = 1,791) with hypertension received stepped treatment to maintain blood pressure below the target of 130/8 0mmHg in standard and intensive glycemic treatment groups.
5 Participants in the VADT (n = 1,791) with hypertension (72.1% of total) received stepped treatment to maintain blood pressure below the target of 130/80 mm Hg in standard and intensive glycemic treatment groups.
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