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The threats Yarst and Vasilenko personally received escalated, almost daily, via text message, phone calls and, finally, being placed under surveillance.
With first order conditional estimation, a base structural model was built with proportional and additive residual error considering both between-subject variability (BSV) and between-occasion variability (BOV) on PK parameters, since PK data was available on two occasions from patients who received escalated doses.
In this phase I trial, patients received escalated doses of oral everolimus (5, 7.5, and 10 mg/day) in combination with intravenous MMC 5 mg/m every 3 weeks.
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Nine nucleoside analog-naïve, high-risk patients received escalating doses of CAR therapy.
In phase I (n = 22), each cohort received escalating doses of TS-1 (30 40 mg/m2 b.i.d).
Vázquez had also received escalating threats and constant unwanted police attention.
The study consisted of two 4 week phases, separated by a 1 week 'wash-out' period, in which patients received escalating dosages of either placebo or nortriptyline.
Worse, 107 companies were issued with fixed penalty notices requiring them to pay £400, while two employers received escalating penalty notices.
In this phase I study, we enrolled 14 patients with high-risk hematologic malignancies who received escalating doses of TMI at 3 Gy (n = 3), 6 Gy (n = 3), 9 Gy (n = 6), and 12 Gy (n = 2) in combination with intravenous (i.v).v
Therefore, the Bayesian approach has received escalating attention in SEM applications due to its flexibility and better representation of the theory.
Between September 1991 and November 1998, 41 patients with advanced epithelial ovarian cancer received escalating doses of IP (IP) cisplatin (six cycles given every 3-4 weeks) and whole abdomen hyperthermia with intravenous thiosulphate as second line treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com