John McCain and his campaign received a serious setback a couple of days ago he was endorsed by President Bush.
European integration recently received a serious setback with the referendum defeat of the European Union's draft constitution in the Netherlands and France.
Mr. Valle's contention also received a severe response from Senator Martin J. Golden, a Brooklyn Republican.
On the whole, I believe that the consequences of the crackdown have been a severe setback to the government.
The doctor involved with the operation has been arrested, and it's been reported that polio vaccinations have suffered a severe setback regionally.
If a big part of the inventory receives even cosmetic damage, it can be a severe setback, and the delay in getting paid can break a dealer.
This would be a severe setback for Internet users.
The legitimate uses for P2P technology may thus suffer a severe setback.
Their disappearance is a severe setback to Hassan Khan, a prisoner serving life for a 2007 robbery in West Wickham.
Late last year, Mr. Wang had a severe setback when he fell off his bicycle during a delivery and shattered his arm.
There was frantic speculation in the shares of the South Sea Company, resulting in a severe setback to joint-stock enterprise.
