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STUDY DESIGN: Following completion of parenteral therapy, infants with central nervous system and/or disseminated disease received 2 years of continuous oral acyclovir therapy.
METHOD: Adult outpatients (N = 59) with chronic or recurrent major depressive disorder or bipolar (I or II) disorder and experiencing a treatment-resistant, nonpsychotic MDE (DSM-IV criteria) received 2 years of VNS.
All patients received 2 years of adjuvant tamoxifen treatment, without stratification according to ER status.
Until 1998 post-menopausal node-positive patients received 2 years tamoxifen.
Most male patients received 2 years of maintenance ALL therapy (i.e., approximately 3 years treatment in total), and therefore received a greater cumulative dose of steroid treatment than females, who only received 1 year of maintenance.
One study reported high expression of EGFR to be inversely correlated with nodal metastases and shorter, distant disease-free survival in a group of breast cancer patients who had received 2 years of adjuvant tamoxifen treatment (Dihge et al, 2008).
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