The extend step receives alignments that passed the filter step.
Each pair of terms which is aligned receives an alignment score ranging from 0 to 1 where 1 represents identity in both intrinsic and relational similarity.
Given the library, any pair of residues receives an alignment score equal to the number of time these two residues have been found aligned, either directly or indirectly through a third residue (Fig. 1).
Most of these were from the UK (57%), followed by the US, Canada, France, and Germany.> -wrap-foot>> In the first 6 months, when the first batch of puzzles was retired, we received 154,038 alignment answers, with an approximate log-normal distribution of answers for 10,087 puzzles.
Here, both subtasks in sequence alignment are concerned: it is possible that, due to repeats, biologically meaningful alignments receive lower scores than alternative, yet biologically unreasonable alignments.
It has always been clear to most medical professionals that robust communication around advance care planning is in the patient's best interest, and that it provides the best means for patients to make sure that the treatment they receive is in alignment with both their doctor's advice and their own wishes and goals.
Finally, we removed sites that occur within a total of 17 Mb of the genome that receive excess read alignment in 1000 Genome Project data (Genovese et al., 2013).
MegaBLAST localizations align up to, but not beyond, exon boundaries in 35% of attempts, with only 11% of exons receiving perfect alignments at both edges.
The maximum score that an alignment can receive is the same as the number of pairs in the consensus secondary structure.
Each puzzle was played on average by 11.48 (standard deviation 7.08) players, and not all alignment answers were informative (we received 3.6 empty alignments per puzzle; Supplementary file 1, Table S1).
