Among fully-vaccinated children, all were assumed to be unprotected against RV infection before receipt of dose 1, partially protected during the course of vaccination schedule, and fully protected following receipt of the last dose (as described under Vaccine Effectiveness).
In the M/P group, a total of 12 of 24 SAEs occurred after receipt of dose 3 (ie, when subjects had received both study drugs).
Due to the higher frequencies of level 3 AEs (as the highest severity) and SAEs in the M/P treatment group, a post hoc analysis was performed to determine the incidence of AEs before and after receipt of dose 3 (when the switch to the second study drug occurred).
Some of these differences persisted after receipt of dose 3 of study drug, with the M/P group exhibiting higher rates of level 3 AEs (as the highest severity) and SAEs compared with either the motavizumab-only (control) or the P/M treatment group.
We defined women as unvaccinated (no doses), partially vaccinated (one or two doses), or fully vaccinated (≥3 doses) where receipt of vaccine doses occurred at any point before the index date.
A number of important insights to this have arisen from the study of a cohort of Irish women who were accidentally exposed to HCV after receipt of doses of infected anti-D immunoglobulin.
Plasma samples were collected from subjects on the first and last days of therapy, before dose receipt and approximately 3 5 hours (intended) after dose receipt.
Based on the frequency of dosing, completion of IFN therapy was defined as receipt of 20 doses intravenously during the induction phase and 144 doses of self-administered subcutaneous injections during the maintenance phase.
CHIS-recorded receipt of MMR dose(s) during the first year of the catch-up campaign (1st September 2008 31st August 2009), and postcode-level Indices of Multiple Deprivation 2007 data (IMD2007 [13]), were obtained for the entire sample including non-respondents.
Plasma samples were collected before and after dose receipt on the first and last days of therapy, and fecal samples were collected on the last day of therapy.
