Sentence examples for recapitulating two from inspiring English sources

Our tool predicts the experimentally observed structure of two possible Aβ conformations, recapitulating two distinct experimental models of the peptide based on NMR, H/D-exchange and mutational analysis (Lührs et al., 2005; Petkova et al., 2003).

Another major finding in this study is the presence of RNA foci and RAN translation products in iPSCs-derived human neurons, recapitulating two major neuropathological features of FTD patients with C9ORF72 repeat expansion.

When poly I C challenges were made in triple transgenic mice containing mutations in APP, PS1 and Tau, inflammation induced APP fragments to act as a seeding point for senile human-like Aβ deposits and drove Tau tangle-like structures in neuronal somata, thus recapitulating two key features of human disease, with systemic inflammation as a driver.

Her story recapitulates two centuries of mid-American Shakespeare.

These latter two phenotypes recapitulate two cardinal features of ATRX-mutant adult and pediatric gliomas, namely widespread tumor cell invasion into surrounding brain and astrocytic histopathology30.

Intriguingly, the increased cellular motility and astrocytic histiogenic profile induced by Atrx deficiency in this in vitro model recapitulate two of the hallmark features associated with diffuse astrocytoma, the predominant ATRX-mutant human glioma subtype30.

Thus, we were able to recapitulate two main adverse birth outcomes associated with PM – spontaneous abortion and IUGR – with this experimental mouse model.

Applying this system to a human cell line, we successfully recapitulated two types of pathogenic chromosomal translocations in human diseases: MYC/IgH and BCR/ABL1.

Thus, this mutant recapitulates two important features of human neurodegenerative diseases, i.e., vulnerability of certain neuronal populations and progressive degeneration, offering a unique scenario in which to unravel the specific mechanisms in an easily tractable organism.

This has implications for how we view mouse models of AD, in that to our knowledge, this is the first mouse model of AD that recapitulates two of the canonical hallmarks of AD pathology: plaques, and hyperphosphorylated tau, without resorting to overexpression of both mutant human proteins.

In addition to simulating the grooming progression, the model recapitulates two other important features of our experimental data.