Sentence examples for recapitulating the effect of from inspiring English sources

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The histone deacetylase inhibitor (HDACi), Romidepsin, specifically restored CDKN1C expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation, recapitulating the effect of SMARCB1 on CDKNIC allelic expression, and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines.

In addition, knock down of EGFR in MDA-MB-468 cells greatly attenuated tumor growth, recapitulating the effect of miR-27a induction or p53 knockdown.

Furthermore, ectopic expression of Mcl1 in control cells increased slippage and reduced death in DME-treated cells, recapitulating the effect of Ras activation.

Importantly, ectopic overexpressing SRF in GC9811 cells caused an increase of luciferase activity in wild-type miR-199a-1 miR-199a-1 miR-199a-1andtulating the effect of transcriptional activation observed in GC9811-P cells.

The absence of any significant additive effect when Esrrb is overexpressed in the presence of CH suggests that Esrrb is capable of fully recapitulating the effect of Gsk3 inhibition on ESC clonogenicity.

While the Akt acetylation-defective mutant, K20R, exhibits increased PIP3 binding and Akt membrane localization, the K20Q mutant that mimics constitutive Akt acetylation increases Akt activity, recapitulating the effect of SIRT1 deficiency.

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Similar(52)

These simulations allow recapitulating the effects of the history of dose delivery on the growth processes of gold nanostructures.

Silencing of Mediator subunits resulted in suppression of stem cell genes, thus recapitulating the effects of BRD4 inhibition on the ESC transcriptional network.

Furthermore, sh Brd4-derived tumors displayed induction of neuroectodermal markers (i.e., NeuN), recapitulating the effects of BET inhibition in vitro in lineage commitment.

Our model relevantly recapitulates the effect of oncolytic adenovirus; tumor responses in this setting nearly reproduce those observed in vivo.

Perhaps, S to D mutation only partially recapitulates the effect of phosphorylation.

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